High-resolution profiling of human cytomegalovirus cell-free DNA in human plasma highlights its exceptionally fragmented nature.
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ABSTRACT:
SUBMITTER: Peddu V
PROVIDER: S-EPMC7048871 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
High-resolution profiling of human cytomegalovirus cell-free DNA in human plasma highlights its exceptionally fragmented nature.
Peddu Vikas V Bradley Benjamin T BT Casto Amanda M AM Shree Raj R Colbert Brice G BG Xie Hong H Santo Tracy K TK Huang Meei-Li ML Cheng Edith Y EY Konnick Eric E Salipante Stephen J SJ Jerome Keith R KR Lockwood Christina M CM Greninger Alexander L AL
Scientific reports 20200228 1
Human cytomegalovirus (CMV) infections comprise a leading cause of newborn impairments worldwide and are pervasive concerns among the immunocompromised. Quantification of CMV viral loads is increasingly used to guide definitions of CMV disease but standardization of CMV quantitation remains problematic, mostly due to differences in qPCR amplicon sizes between clinical laboratories. Here, we used plasma cfDNA sequencing data from 2,208 samples sent for non-invasive prenatal aneuploidy screening t ...[more]
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