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Profiling the urinary microbiome in men with calcium-based kidney stones.

ABSTRACT: BACKGROUND:The dogma that urine is sterile in healthy individuals has been overturned by recent studies applying molecular-based methods. Mounting evidences indicate that dysbiosis of the urinary microbiota is associated with several urological diseases. In this study, we aimed to investigate the urinary microbiome of male patients with calcium-based kidney stones and compare it with those of healthy individuals. RESULTS:The diversity of the urinary microbiota in kidney stone patients was significantly lower than that of healthy controls based on the Shannon and Simpson index (P?

SUBMITTER: Xie J

PROVIDER: S-EPMC7049185 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Profiling the urinary microbiome in men with calcium-based kidney stones.

Xie Jing J Huang Jian-Sheng JS Huang Xiang-Jiang XJ Peng Jun-Ming JM Yu Zhou Z Yuan Ye-Qing YQ Xiao Ke-Feng KF Guo Ji-Nan JN

BMC microbiology 20200228 1

<h4>Background</h4>The dogma that urine is sterile in healthy individuals has been overturned by recent studies applying molecular-based methods. Mounting evidences indicate that dysbiosis of the urinary microbiota is associated with several urological diseases. In this study, we aimed to investigate the urinary microbiome of male patients with calcium-based kidney stones and compare it with those of healthy individuals.<h4>Results</h4>The diversity of the urinary microbiota in kidney stone pati ...[more]

PMID: 32111156

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Delineating the Role of the Urinary Metabolome in the Lithogenesis of Calcium-Based Kidney Stones.

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