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Evening exercise is associated with lower odds of visual field progression in Chinese patients with primary open angle glaucoma.

ABSTRACT: Background:Exercise is widely known to lower intraocular pressure and increase ocular blood flow, which may be beneficial for glaucoma management. However, there are few studies that have reported on the relationship between exercise and glaucoma progression. The aim of our study was to investigate the exercise habits of those with primary open angle glaucoma (POAG) and its association with the progression of visual field (VF) loss. Methods:Daily physical activity (PA) was monitored by an accelerometer (ActiGraph wGT3x-BT) which patients wore for more than 10?h of being awake on their right wrists for 1 week. Results:Seventy-one non-progressive and 27 progressive patients were enrolled in the study. 24-h moderate to vigorous physical activity (MVPA) exercise showed that POAG patients had similar variation trends consisting of 3 wave peaks and 2 wave hollows. Minutes spent in MVPA was 19.89?±?15.81 and 21.62?±?15.10 during 07:00-09:00?h (p?=?0.204), 15.40?±?14.49 and 15.67?±?12.43 during 15:00-17:00?h (p?=?0.822) and 17.26?±?21.11 and 11.42?±?11.58 during 18:00-20:00?h (p?=?0.001) in the non-progressive and progressive group, respectively. Univariate analysis indicated that 10?min of MVPA (18:00-20:00?h) [odds ratio, OR (95% CI)?=?0.82 (0.73, 0.92)], average mean arterial pressure [OR (95% CI)?=?0.96 (0.94, 0.98)], age [OR (95% CI)?=?1.06 (1.03, 1.08)], male [OR (95% CI)?=?0.67 (0.48, 0.96)], spherical equivalent [OR (95% CI)?=?1.14 (1.07, 1.22)] and IOP-lowering medications [OR (95% CI)?=?1.54 (1.16, 2.05)] were significantly correlated with having progressive VF damage. Multivariable analysis showed that 10?min of MVPA (18:00-20:00?h) [OR (95% CI)?=?0.85 (0.75, 0.97)] was associated with progressive VF loss even after adjusting for other risk factors. Conclusions:Evening exercise may lower the odds of VF progression, suggesting that exercise habits possibly play an important role in glaucoma progression.

SUBMITTER: Pan X

PROVIDER: S-EPMC7049389 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Evening exercise is associated with lower odds of visual field progression in Chinese patients with primary open angle glaucoma.

Pan Xiafei X Xu Kai K Wang Xin X Chen Guofu G Cheng Huanhuan H Liu Alice Jia AJ Hou Laurence Tang LT Zhong Lin L Chen Jie J Liang Yuanbo Y

Eye and vision (London, England) 20200301

<h4>Background</h4>Exercise is widely known to lower intraocular pressure and increase ocular blood flow, which may be beneficial for glaucoma management. However, there are few studies that have reported on the relationship between exercise and glaucoma progression. The aim of our study was to investigate the exercise habits of those with primary open angle glaucoma (POAG) and its association with the progression of visual field (VF) loss.<h4>Methods</h4>Daily physical activity (PA) was monitor ...[more]

PMID: 32140501

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Project description:PURPOSE:To characterize OCT angiography (OCT-A) vessel density of patients with primary open-angle glaucoma (POAG) with unilateral visual field (VF) loss. DESIGN:Cross-sectional study. PARTICIPANTS:A total of 33 patients with POAG with a VF defect in 1 eye (mean VF mean deviation [MD], -3.9±3.1 decibels [dB]) and normal VF in the other eye (mean VF MD, -0.2±0.9 dB) and 33 healthy eyes. METHODS:All subjects underwent OCT-A imaging, spectral-domain (SD)-OCT imaging, and VF testing. OCT-A retinal vascular measurements were summarized as whole image vessel density (wiVD), circumpapillary vessel density (cpVD), and parafoveal vessel density (pfVD). Inter-eye differences in vascular measures, as well as SD OCT retinal nerve fiber layer (RNFL), macular ganglion cell complex (mGCC) thickness, and rim area measurements in glaucoma and healthy eyes were compared. Areas under the receiver operating characteristic curves (AUROCs) were used to evaluate diagnostic accuracy for differentiating between unaffected eyes of patients with POAG and healthy eyes. MAIN OUTCOME MEASURES:Difference in OCT-A vessel density and SD OCT structural parameters between unaffected eyes of patients with POAG with the fellow affected eyes and healthy controls. RESULTS:Mean wiVD in unaffected eyes of patients with POAG (52.0%) was higher than in their fellow affected eyes (48.8%) but lower than in healthy eyes (55.9%; P < 0.001). Mean circumpapillary RNFL (cpRNFL) thickness, mGCC thickness, and rim area measurement in unaffected eyes of patients with POAG (87.5 μm, 87.7 μm, and 1.0 mm2) were also higher than those measurements in their fellow eyes (76.5 μm, 79.5 μm, and 0.8 mm2; P < 0.001) and lower than in healthy eyes (98.0 μm, 94.5 μm, and 1.4 mm2; P < 0.001). The AUROCs for differentiating unaffected eyes of patients with POAG from healthy eyes were highest for wiVD (0.84), followed by mGCC (0.78), cpRNFL (0.77), and pfVD (0.69). CONCLUSIONS:OCT-A measures detect changes in retinal microvasculature before VF damage is detectable in patients with POAG, and these changes may reflect damage to tissues relevant to the pathophysiology of glaucoma. Longitudinal studies are needed to determine whether OCT-A measures can improve the detection or prediction of the onset and progression of glaucoma.

Dataset Information

Evening exercise is associated with lower odds of visual field progression in Chinese patients with primary open angle glaucoma.

Publications

Evening exercise is associated with lower odds of visual field progression in Chinese patients with primary open angle glaucoma.

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