NLRP3 Inflammasome and Inflammatory Diseases.
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ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC7049400 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
NLRP3 Inflammasome and Inflammatory Diseases.
Wang Zheng Z Zhang Simei S Xiao Ying Y Zhang Wunai W Wu Shuai S Qin Tao T Yue Yangyang Y Qian Weikun W Li Li L
Oxidative medicine and cellular longevity 20200217
Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized. ...[more]
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