Ontology highlight
ABSTRACT:
SUBMITTER: Begka C
PROVIDER: S-EPMC7049660 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Begka Christina C Pattaroni Céline C Mooser Catherine C Nancey Stéphane S McCoy Kathy D KD Velin Dominique D Maillard Michel H MH
iScience 20200208 3
Expression of Toll-interacting protein (Tollip), a potent TLR modulator, decreases in patients with inflammatory bowel diseases (IBD), whereas Tollip<sup>-/-</sup> mice are susceptible to colitis. Tollip expression was shown to be reduced in sporadic adenoma. In contrast, we found variable Tollip expression in patients with colitis-associated adenomas. In Tollip<sup>-/-</sup> mice challenged to develop colitis-associated cancer (CAC), tumor formation was significantly reduced owing to decreased ...[more]