Ontology highlight
ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC7049804 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Feng Xing X Feng Xing X Ma Dong D Zhao Jiabao J Song Yongxi Y Zhu Yuekun Y Zhou Qingxin Q Ma Fei F Liu Xing X Zhong Mengya M Liu Yu Y Xiong Yubo Y Qiu Xingfeng X Zhang Zhen Z Zhang Heng H Zhao Yongxiang Y Zhang Kaiguang K Hong Xuehui X Zhang Zhiyong Z
The EMBO journal 20200123 5
UHMK1 is a nuclear serine/threonine kinase recently implicated in carcinogenesis. However, the functions and action mechanisms of UHMK1 in the pathogenesis of human gastric cancer (GC) are unclear. Here, we observed that UHMK1 was markedly upregulated in GC. UHMK1 silencing strongly inhibited GC aggressiveness. Interestingly, UHMK1-induced GC progression was mediated primarily via enhancing de novo purine synthesis because inhibiting purine synthesis reversed the effects of UHMK1 overexpression. ...[more]