Unknown

Dataset Information

0

Access to Clinical Trials for Adolescents and Young Adults With Cancer: A Meta-Research Analysis.

ABSTRACT: Background:The 18-year-old age limit for inclusion in clinical trials constitutes a hurdle for adolescents and young adults (AYAs) with cancer. We analyzed the impact of this age barrier on the access of AYAs to cancer trials and novel therapies. Methods:ClinicalTrials.gov was searched to identify all the trials including patients with 10 malignancies relevant for AYAs (January 2007 to July 2018). The trials were categorized as pediatric (patients <18?y), adult (?18?y), and transitional (including adult and pediatric patients). Transitional trials with a lower limit between 12 and 18?years and an upper limit younger than 40?years were considered AYA-specific. Results:Of 2764 identified trials, 2176 were included: 79% adult, 19% transitional, 2% pediatric. Five trials were AYA-specific. The proportion of academic trials was higher for transitional (69%; 288 of 421) than for adult trials (48%; 832 of 1718) (P

SUBMITTER: de Rojas T 

PROVIDER: S-EPMC7050014 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Access to Clinical Trials for Adolescents and Young Adults With Cancer: A Meta-Research Analysis.

de Rojas Teresa T   Neven Anouk A   Terada Mitsumi M   García-Abós Miriam M   Moreno Lucas L   Gaspar Nathalie N   Péron Julien J  

JNCI cancer spectrum 20190801 4

<h4>Background</h4>The 18-year-old age limit for inclusion in clinical trials constitutes a hurdle for adolescents and young adults (AYAs) with cancer. We analyzed the impact of this age barrier on the access of AYAs to cancer trials and novel therapies.<h4>Methods</h4>ClinicalTrials.gov was searched to identify all the trials including patients with 10 malignancies relevant for AYAs (January 2007 to July 2018). The trials were categorized as pediatric (patients <18 y), adult (≥18 y), and transi  ...[more]

Similar Datasets

Unknown Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era.
| S-EPMC7064039 | biostudies-literature
Unknown The Clinical Trials Gap for Adolescents and Young Adults with Cancer: Recent Progress and Conceptual Framework for Continued Research.
| S-EPMC6319956 | biostudies-literature
Unknown Role of clinical trials in survival progress of American adolescents and young adults with cancer-and lack thereof.
| S-EPMC6077840 | biostudies-other
Unknown Improving recruitment and retention of adolescents and young adults with cancer in randomized controlled clinical trials.
| S-EPMC7048696 | biostudies-literature
Unknown Conducting Psychosocial Intervention Research among Adolescents and Young Adults with Cancer: Lessons from the PRISM Randomized Clinical Trial.
| S-EPMC6915330 | biostudies-literature
Unknown Perceptions of and decision making about clinical trials in adolescent and young adults with Cancer: a qualitative analysis.
| S-EPMC5987432 | biostudies-literature
Unknown Litigation seeking access to data from ongoing clinical trials: a threat to clinical research.
| S-EPMC5758866 | biostudies-literature
Unknown Gynecological cancer among adolescents and young adults (AYA).
| S-EPMC7186636 | biostudies-literature
Unknown Minorities remain underrepresented in HIV/AIDS research despite access to clinical trials.
| S-EPMC4031907 | biostudies-literature
Unknown Orthopedic toxicities among adolescents and young adults treated in DFCI ALL Consortium Trials.
| S-EPMC8753211 | biostudies-literature