Ontology highlight
ABSTRACT:
SUBMITTER: Gregory KS
PROVIDER: S-EPMC7050238 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
FEBS open bio 20200128 3
Botulinum neurotoxins (BoNTs) are one of the most toxic proteins known to humans. Their molecular structure is comprised of three essential domains-a cell binding domain (H<sub>C</sub> ), translocation domain and catalytic domain (light chain) . The H<sub>C</sub> domain facilitates the highly specific binding of BoNTs to the neuronal membrane via a dual-receptor complex involving a protein receptor and a ganglioside. Variation in activity/toxicity across subtypes of serotype A has been attribute ...[more]