Early cardiac dysfunction in children and young adults with perinatally acquired HIV.
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ABSTRACT: Objective
To define the prevalence of early cardiac dysfunction in children and young adults with perinatally acquired HIV and predictors of cardiac function.Design
Cross-sectional design.Methods
Early cardiac dysfunction was defined as left ventricular (LV) global longitudinal strain z-score less than -2 or myocardial performance index at least 0.5 with normal LV ejection fraction. Regression models were fitted to assess the relationship between measures of cardiac function and HIV RNA levels, clinical variables, and markers of inflammation.Results
Six hundred and forty-three individuals (mean age 14.1?±?5.2 years) were enrolled. The average time on combination antiretroviral treatment was 6.8?±?3.6 years. Nearly 28% of individuals met criteria for early cardiac dysfunction. Individuals with early cardiac dysfunction were older (15.3 vs. 13.5 years, P?ConclusionOver one-quarter of children and young adults living with HIV demonstrated evidence of cardiac dysfunction, which may be associated with increasing levels of systemic inflammation.
SUBMITTER: McCrary AW
PROVIDER: S-EPMC7050370 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Early cardiac dysfunction in children and young adults with perinatally acquired HIV.
McCrary Andrew W AW Nyandiko Winstone M WM Ellis Alicia M AM Chakraborty Hrishikesh H Muehlbauer Michael J MJ Koech Myra M MM Daud Ibrahim I Birgen Elcy E Thielman Nathan M NM Kisslo Joseph A JA Barker Piers C A PCA Bloomfield Gerald S GS
AIDS (London, England) 20200301 4
<h4>Objective</h4>To define the prevalence of early cardiac dysfunction in children and young adults with perinatally acquired HIV and predictors of cardiac function.<h4>Design</h4>Cross-sectional design.<h4>Methods</h4>Early cardiac dysfunction was defined as left ventricular (LV) global longitudinal strain z-score less than -2 or myocardial performance index at least 0.5 with normal LV ejection fraction. Regression models were fitted to assess the relationship between measures of cardiac funct ...[more]
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