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Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent.

ABSTRACT: Hybrid molecules have been developed which are comprised of a tyrosine kinase-targeted, quinazoline-based scaffold and a flexibly linked dia(m)minechloridoPt(ii) moiety. The target compounds maintain high affinity and selectivity for ErbB family kinase proteins and one of the derivatives induces platinum adducts with a pharmacologically important cysteine residue.

SUBMITTER: Yang M

PROVIDER: S-EPMC7050444 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent.

Yang Mu M Wu Hanzhi H Chu Julie J Gabriel Lucas A LA Kim Y Y Anderson Karen S KS Furdui Cristina M CM Bierbach Ulrich U

Chemical communications (Cambridge, England) 20180619 54

Hybrid molecules have been developed which are comprised of a tyrosine kinase-targeted, quinazoline-based scaffold and a flexibly linked dia(m)minechloridoPt(ii) moiety. The target compounds maintain high affinity and selectivity for ErbB family kinase proteins and one of the derivatives induces platinum adducts with a pharmacologically important cysteine residue. ...[more]

PMID: 29915817

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