Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models.

ABSTRACT:

Aim

According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action.

Materials & methods

We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors.

Results & conclusion

Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the like

SUBMITTER: Giolito MV 

PROVIDER: S-EPMC7050605 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature