Drug-Induced Rhabdomyolysis Atlas (DIRA) for idiosyncratic adverse drug reaction management.
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ABSTRACT:
SUBMITTER: Wen Z
PROVIDER: S-EPMC7050640 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
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Drug-Induced Rhabdomyolysis Atlas (DIRA) for idiosyncratic adverse drug reaction management.
Wen Zhining Z Liang Yu Y Hao Yingyi Y Delavan Brian B Huang Ruili R Mikailov Mike M Tong Weida W Li Menglong M Liu Zhichao Z
Drug discovery today 20180611 1
Drug-induced rhabdomyolysis (DIR) is an idiosyncratic and fatal adverse drug reaction (ADR) characterized in severe muscle injuries accompanied by multiple-organ failure. Limited knowledge regarding the pathophysiology of rhabdomyolysis is the main obstacle to developing early biomarkers and prevention strategies. Given the lack of a centralized data resource to curate, organize, and standardize widespread DIR information, here we present a Drug-Induced Rhabdomyolysis Atlas (DIRA) that provides ...[more]
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