Dataset Information

Limited Positive Predictive Value of ?-d-Glucan in Hematologic Patients Receiving Antimold Prophylaxis.

ABSTRACT: Background:Diagnostic value of ?-d-glucan (BDG) in populations with low prevalence of invasive fungal infection (IFI), such as hematologic patients receiving antimold prophylaxis, should be re-evaluated. Methods:We retrospectively reviewed episodes with BDG results in hematologic patients receiving antimold prophylaxis from January 2017 to August 2019 in a tertiary hospital. The episodes were classified as true positive ([TP] positive BDG with IFI), true negative ([TN] negative BDG without IFI), false positive ([FP] positive BDG without IFI), false negative ([FN] negative BDG with IFI), and nonevaluable. Results:A total of 203 episodes were analyzed: 101 episodes (49.8%) were from stem cell transplants, 89 (43.8%) were from induction chemotherapy, and 13 (6.4%) were from graft-versus-host disease treatment. There were 62 nonevaluable episodes. Among 141 evaluable ones, there were 8 (5.7%) episodes of probable/proven IFI. True positive, TN, FP, and FN cases were 4 (2.8%), 112 (79.4%), 21 (14.9%), and 4 (2.8%) episodes, respectively. Sensitivity, specificity, positive predictive value, and negative predictive value were 50.0%, 84.2%, 16.1%, and 96.5%, respectively. Positive predictive value was 26.7% and 0.0% in diagnostic and surveillance episodes, respectively. Conclusions:?-d-glucan test should be used to exclude IFI rather than for diagnosis in these patients.

SUBMITTER: Chang E

PROVIDER: S-EPMC7051035 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Limited Positive Predictive Value of β-d-Glucan in Hematologic Patients Receiving Antimold Prophylaxis.

Chang Euijin E Kim Taek Soo TS Kang Chang Kyung CK Jun Kang Il KI Shin Dongyeop D Koh Youngil Y Hong Junshik J Choe Pyoeng Gyun PG Park Wan Beom WB Kim Nam-Joong NJ Yoon Sung-Soo SS Kim Inho I Oh Myoung-Don MD

Open forum infectious diseases 20200212 3

<h4>Background</h4>Diagnostic value of β-d-glucan (BDG) in populations with low prevalence of invasive fungal infection (IFI), such as hematologic patients receiving antimold prophylaxis, should be re-evaluated.<h4>Methods</h4>We retrospectively reviewed episodes with BDG results in hematologic patients receiving antimold prophylaxis from January 2017 to August 2019 in a tertiary hospital. The episodes were classified as true positive ([TP] positive BDG with IFI), true negative ([TN] negative BD ...[more]

PMID: 32158776

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Dataset Information

Limited Positive Predictive Value of ?-d-Glucan in Hematologic Patients Receiving Antimold Prophylaxis.

Publications

Limited Positive Predictive Value of β-d-Glucan in Hematologic Patients Receiving Antimold Prophylaxis.

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