Ontology highlight
ABSTRACT:
SUBMITTER: Renner M
PROVIDER: S-EPMC7051845 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Renner Max M Flanagan Aleksandra A Dejnirattisai Wanwisa W Puttikhunt Chunya C Kasinrerk Watchara W Supasa Piyada P Wongwiwat Wiyada W Chawansuntati Kriangkrai K Duangchinda Thaneeya T Cowper Alison A Midgley Claire M CM Malasit Prida P Huiskonen Juha T JT Mongkolsapaya Juthathip J Screaton Gavin R GR Grimes Jonathan M JM
Nature immunology 20181015 11
Dengue virus is a major pathogen, and severe infections can lead to life-threatening dengue hemorrhagic fever. Dengue virus exists as four serotypes, and dengue hemorrhagic fever is often associated with secondary heterologous infections. Antibody-dependent enhancement (ADE) may drive higher viral loads in these secondary infections and is purported to result from antibodies that recognize dengue virus but fail to fully neutralize it. Here we characterize two antibodies, 2C8 and 3H5, that bind t ...[more]