Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity.

ABSTRACT:

Introduction

Several plasma metabolites have been associated with insulin resistance and type 2 diabetes mellitus.

Objectives

We aimed to identify plasma metabolites associated with different indices of early disturbances in glucose metabolism and insulin sensitivity.

Methods

This cross-sectional study was conducted in a subsample of the Leiden Longevity Study comprising individuals without a history of diabetes mellitus (n = 233) with a mean age of 63.3 ± 6.7 years of which 48.1% were men. We tested for associations of fasting glucose, fasting insulin, HOMA-IR, Matsuda Index, Insulinogenic Index and glycated hemoglobin with metabolites (Swedish Metabolomics Platform) using linear regression analysis adjusted for age, sex and BMI. Results were validated internally usi

SUBMITTER: Bos MM 

PROVIDER: S-EPMC7051926 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature