Unknown

Dataset Information

0

Tumor-educated B cells promote renal cancer metastasis via inducing the IL-1?/HIF-2?/Notch1 signals.

ABSTRACT: While B cells in the tumor microenvironment (TME) might play important roles in cancer progression, their impacts on the renal cell carcinoma (RCC) metastasis remained unclear, which drew our attention to further explore. We found that RCC tissues could recruit more B cells than the surrounding normal renal tissues from human clinical RCC samples. Wound healing assay, transwell assay and 3D invasion assays demonstrated that recruited B cells, also known as tumor-educated B cells (TEB), could significantly increase the RCC cell migration and invasion. In addition, in vivo data from xenograft RCC mouse model also confirmed that TEB could enhance RCC cell invasive and metastatic capability. Mechanism dissection revealed that TEB activated IL-1?/HIF-2? signals in RCC cells that could induce the downstream Notch1 signaling pathway. The above results demonstrated the key roles of TEB within renal cancer associated tumor microenvironment were metastasis-promotor and might help us to develop the potential therapies via targeting these newly identified IL-1?/HIF-2?/Notch1 signals in RCC progression.

SUBMITTER: Li S 

PROVIDER: S-EPMC7052134 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Tumor-educated B cells promote renal cancer metastasis via inducing the IL-1β/HIF-2α/Notch1 signals.

Li Saiyang S   Huang Chi C   Hu Guanghui G   Ma Junjie J   Chen Yonghui Y   Zhang Jin J   Huang Yiran Y   Zheng Junhua J   Xue Wei W   Xu Yunfei Y   Zhai Wei W  

Cell death & disease 20200302 3

While B cells in the tumor microenvironment (TME) might play important roles in cancer progression, their impacts on the renal cell carcinoma (RCC) metastasis remained unclear, which drew our attention to further explore. We found that RCC tissues could recruit more B cells than the surrounding normal renal tissues from human clinical RCC samples. Wound healing assay, transwell assay and 3D invasion assays demonstrated that recruited B cells, also known as tumor-educated B cells (TEB), could sig  ...[more]

Similar Datasets

Unknown Tumor-Educated Neutrophils Activate Mesenchymal Stem Cells to Promote Gastric Cancer Growth and Metastasis.
| S-EPMC7438587 | biostudies-literature
Unknown RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis.
| S-EPMC5226067 | biostudies-literature
Unknown Tumor-educated Gr1+CD11b+ cells drive breast cancer metastasis via OSM/IL-6/JAK-induced cancer cell plasticity.
| S-EPMC10940099 | biostudies-literature
Unknown Tumor-associated macrophages-educated reparative macrophages promote diabetic wound healing.
| S-EPMC9906426 | biostudies-literature
Unknown Tumor-associated macrophages in direct contact with prostate cancer cells promote malignant proliferation and metastasis through NOTCH1 pathway.
| S-EPMC9682538 | biostudies-literature
Unknown Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway.
| S-EPMC7590195 | biostudies-literature
Unknown Tumor-driven like macrophages induced by conditioned media from pancreatic ductal adenocarcinoma promote tumor metastasis via secreting IL-8.
| S-EPMC6246928 | biostudies-literature
Unknown Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1?/Jagged1/Notch1 signaling.
| S-EPMC6148082 | biostudies-other
Unknown WSB1 promotes tumor metastasis by inducing pVHL degradation.
| S-EPMC4647558 | biostudies-literature
Unknown Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals.
| S-EPMC4694886 | biostudies-other