Ontology highlight
ABSTRACT:
SUBMITTER: Chu Z
PROVIDER: S-EPMC7052205 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Chu Zhulang Z Sun Chenming C Sun Lina L Feng Chang C Yang Fan F Xu Yanan Y Zhao Yong Y
Cellular & molecular immunology 20190404 3
Monocytes and macrophages have long been associated with acute and chronic allograft rejection; this is mediated by their abilities to promote inflammation, kill target cells via antibody-dependent cytotoxicity and modulate adaptive immunity. Our present study showed that allogeneic antigen-primed macrophages acutely rejected skin grafts with specificity after adoptive transfer into MHC-matched immunodeficient mice. The ability of primed macrophages to reject allografts essentially requires the ...[more]