Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases.
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ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC7052353 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases.
Frontiers in neurology 20200225
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on the strong paramagnetism of Mn<sup>2+</sup>. Mn<sup>2+</sup> is a calcium ion analog and can enter excitable cells through voltage-gated calcium channels. Mn<sup>2+</sup> can be transported along the axons of neurons via microtubule-based fast axonal transport. Based on these properties, MEMRI is used to describe neuroanatomical structures, monitor neural activity, and evaluate axonal transport rates. The application of MEMRI in pre ...[more]
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