How polypharmacologic is each chemogenomics library?
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ABSTRACT:
SUBMITTER: Ni E
PROVIDER: S-EPMC7052528 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
How polypharmacologic is each chemogenomics library?
Ni Eric E Kwon Eehjoe E Young Lauren M LM Felsovalyi Klara K Fuller Jennifer J Cardozo Timothy T
Future drug discovery 20200205 1
<h4>Aim</h4>High-throughput phenotypic screens have emerged as a promising avenue for small-molecule drug discovery. The challenge faced in high-throughput phenotypic screens is target deconvolution once a small molecule hit is identified. Chemogenomics libraries have emerged as an important tool for meeting this challenge. Here, we investigate their target-specificity by deriving a 'polypharmacology index' for broad chemogenomics screening libraries.<h4>Methods</h4>All known targets of all the ...[more]
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