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Proton beam therapy for liver cancers.


ABSTRACT: Proton beam therapy (PBT) delivers less dose to nearby normal organs compared to X-ray therapy (XRT), which is particularly relevant for treating liver cancers given that both mean and low liver dose are among the most significant predictors of radiation induced liver disease (RILD). High-dose PBT has been shown to achieve excellent long-term tumor control with minimal toxicity in hepatocellular carcinoma (HCC) patients. Increasing data support ablative PBT for patients with unresectable cholangiocarcinoma or liver metastases, especially those with larger tumors not suitable for XRT.

SUBMITTER: Chuong M 

PROVIDER: S-EPMC7052772 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Proton beam therapy for liver cancers.

Chuong Michael M   Kaiser Adeel A   Molitoris Jason J   Mendez Romero Alejandra A   Apisarnthanarax Smith S  

Journal of gastrointestinal oncology 20200201 1


Proton beam therapy (PBT) delivers less dose to nearby normal organs compared to X-ray therapy (XRT), which is particularly relevant for treating liver cancers given that both mean and low liver dose are among the most significant predictors of radiation induced liver disease (RILD). High-dose PBT has been shown to achieve excellent long-term tumor control with minimal toxicity in hepatocellular carcinoma (HCC) patients. Increasing data support ablative PBT for patients with unresectable cholang  ...[more]

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