Calcium Handling Defects and Cardiac Arrhythmia Syndromes.
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ABSTRACT:
SUBMITTER: Kistamas K
PROVIDER: S-EPMC7052815 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Calcium Handling Defects and Cardiac Arrhythmia Syndromes.
Kistamás Kornél K Veress Roland R Horváth Balázs B Bányász Tamás T Nánási Péter P PP Eisner David A DA
Frontiers in pharmacology 20200225
Calcium ions (Ca<sup>2+</sup>) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca<sup>2+</sup> concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular level to drive action potentials and to maintain action potential propagation and electrical homogeneity at the tissue level. Any imbalance in Ca<sup>2+</sup> ho ...[more]
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