Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects.
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ABSTRACT:
SUBMITTER: Pauli CS
PROVIDER: S-EPMC7053164 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects.
Pauli Christopher S CS Conroy Matthieu M Vanden Heuvel Brian D BD Park Sang-Hyuck SH
Frontiers in pharmacology 20200225
This review aims to present completed clinical trial data surrounding the medicinal benefits and potential side effects of the increasingly popular cannabidiol (CBD)-based drug products, specifically Epidiolex. The article is divided into two sections based on if the ailment being treated by this cannabinoid is classified as either physiological or neurological conditions. In addition to describing the current status, we also examined the different primary and secondary outcomes recorded for eac ...[more]
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2014-07-29 | E-GEOD-57571 | biostudies-arrayexpress
Project description:Adverse Drug Reactions (ADRs) have a direct impact on human health. As continuous pharmacovigilance and drug monitoring prove to be costly and time-consuming, computational methods have emerged as promising alternatives. However, most existing computational methods primarily focus on predicting whether or not the drug is associated with an adverse reaction and do not consider the core issue of drug benefit-risk assessment-whether the treatment outcome is serious when adverse drug reactions occur. To this end, we categorize serious clinical outcomes caused by adverse reactions to drugs into seven distinct classes and present a deep learning framework, so-called GCAP, for predicting the seriousness of clinical outcomes of adverse reactions to drugs. GCAP has two tasks: one is to predict whether adverse reactions to drugs cause serious clinical outcomes, and the other is to infer the corresponding classes of serious clinical outcomes. Experimental results demonstrate that our method is a powerful and robust framework with high extendibility. GCAP can serve as a useful tool to successfully address the challenge of predicting the seriousness of clinical outcomes stemming from adverse reactions to drugs.
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