Dataset Information

The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Clinical studies suggest obesity paradoxically increases survival during bacterial infection and sepsis but decreases it with influenza, but these studies are observational. By contrast, animal studies of obesity in infection can prospectively compare obese versus nonobese controls. We performed a systematic review and meta-analysis of animal investigations to further examine obesity's survival effect in infection and sepsis.

Methods

Databases were searched for studies comparing survival in obese versus nonobese controls. We performed a systematic review and meta-analysis of animal investigations to further examine obesity's survival effect in infection and sepsis. Methods. Databases were searched for studies comparing survival in obese versus nonobese animals following bacteria, lipopolysaccharide, or influenza virus challenges.

Results

Twenty-one studies (761 obese and 603 control animals) met the inclusion criteria. Obesity reduced survival in 19 studies (11 significantly) and the odds ratio (95% CI) of survival (0.21(0.13, 0.35); I ²?=?64%, p < 0.01p < 0.01p?n?=?6 studies, 0.21(0.13, 0.34); I ²?=?64%, p < 0.01p?n?=?6 studies, 0.21(0.13, 0.34); I ²?=?64%, p < 0.01p?n?=?6 studies, 0.21(0.13, 0.34); I ²?=?64%, p < 0.01p?n?=?6 studies, 0.21(0.13, 0.34); I ²?=?64%, p < 0.01p < 0.01p?n?=?6 studies, 0.21(0.13, 0.34); I ²?=?31%, p=0.20 and n?=?5, 0.22(0.13, 0.36); I ²?=?0%, p=0.59, respectively), (2) not significantly with cecal ligation and puncture (n?=?4, 0.72(0.08, 6.23); I ²?=?75%, p < 0.01), and (3) significantly with influenza but with high heterogeneity (n?=?6, 0.12(0.04, 0.34); I ²?=?73%, p < 0.01). Obesity's survival effects did not differ significantly comparing the four challenge types (p=0.49). Animal models did not include antimicrobials or glycemic control and study quality was low.

Conclusions

Preclinical and clinical studies together emphasize the need for prospective studies in patients accurately assessing obesity's impact on survival during severe infection.

SUBMITTER: Xu W

PROVIDER: S-EPMC7053456 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis.

Xu Wanying W Pepper Dominique D Sun Junfeng J Welsh Judith J Cui Xizhong X Eichacker Peter Q PQ

Journal of obesity 20200217

<h4>Background</h4>Clinical studies suggest obesity paradoxically increases survival during bacterial infection and sepsis but decreases it with influenza, but these studies are observational. By contrast, animal studies of obesity in infection can prospectively compare obese <i>versus</i> nonobese controls. We performed a systematic review and meta-analysis of animal investigations to further examine obesity's survival effect in infection and sepsis.<h4>Methods</h4>Databases were searched for s ...[more]

PMID: 32211204

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Dataset Information

The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis.

Background

Methods

Results

Conclusions

Publications

The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis.

Similar Datasets

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