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Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents.

ABSTRACT: Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further overcame the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.

SUBMITTER: Lee H

PROVIDER: S-EPMC7053506 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents.

Lee Hamilton H Shahrivarkevishahi Arezoo A Lumata Jenica L JL Luzuriaga Michael A MA Hagge Laurel M LM Benjamin Candace E CE Brohlin Olivia R OR Parish Christopher R CR Firouzi Hamid R HR Nielsen Steven O SO Lumata Lloyd L LL Gassensmith Jeremiah J JJ

Chemical science 20200205 8

Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical <i>in v ...[more]

PMID: 32180926

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