Ontology highlight
ABSTRACT:
SUBMITTER: Xu T
PROVIDER: S-EPMC7053611 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Xu Tianbo T Ruan Hailong H Gao Su S Liu Jingchong J Liu Yuenan Y Song Zhengshuai Z Cao Qi Q Wang Keshan K Bao Lin L Liu Di D Tong Junwei J Shi Jian J Liang Huageng H Yang Hongmei H Chen Ke K Zhang Xiaoping X
Aging 20200130 2
Clear cell renal cell carcinoma (ccRCC) is one of the most common malignancies and lacks reliable biomarkers for diagnosis and prognosis, which results in high incidence and mortality rates of ccRCC. In this study, ISG20, HJURP, and FOXM1 were identified as hub genes via weighted gene co-expression network analysis (WGCNA) and Cox regression analysis. Samples validation showed that only ISG20 was up-regulated in ccRCC. Therefore, ISG20 was selected for further study. High ISG20 expression was as ...[more]