Ontology highlight
ABSTRACT:
SUBMITTER: Tennant JM
PROVIDER: S-EPMC7053746 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Tennant Joanne M JM Li Manci M Henderson Davin M DM Tyer Margaret L ML Denkers Nathaniel D ND Haley Nicholas J NJ Mathiason Candace K CK Hoover Edward A EA
PloS one 20200303 3
CWD is an emergent prion disease that now affects cervid species on three continents. CWD is efficiently spread in wild and captive populations, likely through both direct animal contact and environmental contamination. Here, by longitudinally assaying in feces of CWD-exposed white-tailed deer by RT-QuIC, we demonstrate fecal shedding of prion seeding activity months before onset of clinical symptoms and continuing throughout the disease course. We also examine the impact of simulated environmen ...[more]