Ontology highlight
ABSTRACT:
SUBMITTER: Ellis CR
PROVIDER: S-EPMC7053747 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ellis Christopher R CR Racz Rebecca R Kruhlak Naomi L NL Kim Marlene T MT Zakharov Alexey V AV Southall Noel N Hawkins Edward G EG Burkhart Keith K Strauss David G DG Stavitskaya Lidiya L
PloS one 20200303 3
Kratom is a botanical substance that is marketed and promoted in the US for pharmaceutical opioid indications despite having no US Food and Drug Administration approved uses. Kratom contains over forty alkaloids including two partial agonists at the mu opioid receptor, mitragynine and 7-hydroxymitragynine, that have been subjected to the FDA's scientific and medical evaluation. However, pharmacological and toxicological data for the remaining alkaloids are limited. Therefore, we applied the Publ ...[more]