Genomic basis for RNA alterations in cancer.

ABSTRACT: Transcript alterations often result from somatic changes in cancer genomes¹. Various forms of RNA alterations have been described in cancer, including overexpression², altered splicing³ and gene fusions⁴; however, it is difficult to attribute these to underlying genomic changes owing to heterogeneity among patients and tumour types, and the relatively small cohorts of patients for whom samples have been analysed by both transcriptome and whole-genome sequencing. Here we present, to our knowledge, the most comprehensive catalogue of cancer-associated gene alterations to date, obtained by characterizing tumour transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortiu

SUBMITTER: PCAWG Transcriptome Core Group 

PROVIDER: S-EPMC7054216 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature