Ontology highlight
ABSTRACT:
SUBMITTER: Baddela VS
PROVIDER: S-EPMC7054295 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Baddela Vijay Simha VS Sharma Arpna A Michaelis Marten M Vanselow Jens J
Scientific reports 20200303 1
Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor, consisting of a constitutively expressed β-subunit (HIF1B) and a regulated α-subunit (HIF1A). In the present study, we analyzed the HIF1 driven transcriptional activity in bovine granulosa cells (GC). Treatment of GC with FSH (follicle stimulating hormone) and IGF1 (insulin-like growth factor 1) resulted in the upregulation of HIF1A mRNA expression under normoxia. Immunohistochemistry of bovine ovarian sections showed dis ...[more]