Ontology highlight
ABSTRACT:
SUBMITTER: Ren F
PROVIDER: S-EPMC7054421 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ren Fan F Lin Qiaohong Q Gong Gaorui G Du Xian X Dan Hong H Qin Wenying W Miao Ran R Xiong Yang Y Xiao Rui R Li Xiaohui X Gui Jian-Fang JF Mei Jie J
Communications biology 20200303 1
Early embryogenesis relies on maternally inherited mRNAs. Although the mechanism of maternal mRNA degradation during maternal-to-zygotic transition (MZT) has been extensively studied in vertebrates, how the embryos maintain maternal mRNA stability remains unclear. Here, we identify Igf2bp3 as an important regulator of maternal mRNA stability in zebrafish. Depletion of maternal igf2bp3 destabilizes maternal mRNAs prior to MZT and leads to severe developmental defects, including abnormal cytoskele ...[more]