Ontology highlight
ABSTRACT:
SUBMITTER: Yang DD
PROVIDER: S-EPMC7054453 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yang Dong-Dong DD Chen Zhan-Hong ZH Yu Kai K Lu Jia-Huan JH Wu Qi-Nian QN Wang Yun Y Ju Huai-Qiang HQ Xu Rui-Hua RH Liu Ze-Xian ZX Zeng Zhao-Lei ZL
Frontiers in oncology 20200226
Methyltransferase-like 3 (METTL3), a major component of the N6-methyladenosine (m6A) methyltransferase complex, has been suggested to function as an oncogene in several cancers. However, its biological mechanism and the involved pathways in gastric cancer (GC) remain unknown. Here, we reported that frequent upregulation of METTL3 was responsible for the aberrant m6A levels in gastric carcinoma. On the other hand, a high level of METTL3 was significantly associated with several clinicopathologica ...[more]