Genome analysis of Lactobacillus plantarum subsp. plantarum KCCP11226 reveals a well-conserved C₃₀ carotenoid biosynthetic pathway.

ABSTRACT: Carotenoids are group of colored terpenoids with antioxidant properties and widespread in nature including in microorganisms. Lactobacillus plantarum subsp. plantarum KCCP11226 was previously isolated from kimchi, while exhibiting the production of 4,4'-diaponeurosporene as a C₃₀ carotenoid. In this study, full genome sequencing of the strain KCCP11226 was performed. Genome analysis revealed that the dehydrosqualene synthase (crtM) and dehydrosqualene desaturase (crtN) genes, which are major genes for biosynthesis of 4,4'-diaponeurosporene, were shown to act as an operon in most L. plantarum strains, but they were uncommon in other Lactobacillus species. In vitro experiments revealed that the production of 4,4'-diaponeurosporene w

SUBMITTER: Kim M 

PROVIDER: S-EPMC7054491 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature