Unknown

Dataset Information

0

Higher cholesterol levels, not statin use, are associated with a lower risk of hepatocellular carcinoma.


ABSTRACT: We aimed to examine whether statin users have a lower risk of hepatocellular carcinoma (HCC) after careful consideration of prevalent statin use and cholesterol levels. During a mean prospective follow-up of 8.4 years in 400,318 Koreans, 1686 individuals were diagnosed with HCC. When prevalent users were included, HCC risk was reduced by >50% in statin users, regardless of adjustment for total cholesterol (TC). When prevalent users were excluded, new users who initiated statins within 6 months after baseline had a 40% lower risk of HCC (hazard ratio [HR] = 0.59) in a TC-unadjusted analysis. However, this relationship disappeared (HR = 1.16, 95% CI = 0.80-1.69) after adjusting for TC levels measured within 6 months before statin initiation. TC levels had strong inverse associations with HCC in each model. High cholesterol levels at statin initiation, not statin use, were associated with reduced risk of HCC. Our study suggests no protective effect of statins against HCC.

SUBMITTER: Yi SW 

PROVIDER: S-EPMC7054540 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Higher cholesterol levels, not statin use, are associated with a lower risk of hepatocellular carcinoma.

Yi Sang-Wook SW   Kim Se Hwa SH   Han Ki Jun KJ   Yi Jee-Jeon JJ   Ohrr Heechoul H  

British journal of cancer 20191220 5


We aimed to examine whether statin users have a lower risk of hepatocellular carcinoma (HCC) after careful consideration of prevalent statin use and cholesterol levels. During a mean prospective follow-up of 8.4 years in 400,318 Koreans, 1686 individuals were diagnosed with HCC. When prevalent users were included, HCC risk was reduced by >50% in statin users, regardless of adjustment for total cholesterol (TC). When prevalent users were excluded, new users who initiated statins within 6 months a  ...[more]

Similar Datasets

| S-EPMC7808883 | biostudies-literature
| S-EPMC4188715 | biostudies-literature
| S-EPMC6612541 | biostudies-literature
| S-EPMC6365496 | biostudies-literature
| S-EPMC9938530 | biostudies-literature
| S-EPMC6499123 | biostudies-literature
| S-EPMC7139959 | biostudies-literature
| S-EPMC7056554 | biostudies-literature
| S-EPMC10293910 | biostudies-literature
| S-EPMC6089806 | biostudies-other