A Functional Polymorphism in the Promoter Region of Interleukin-12B Increases the Risk of Colorectal Cancer.

ABSTRACT: Objective:To investigate whether the polymorphisms of interleukin-12B (IL-12B) were associated with the risk of developing colorectal cancer (CRC). Patients and Methods. Genotypes of rs17860508 and rs3212227 were determined by polymerase chain reaction with a direct sequencing method in 329 CRC patients and 342 matched healthy control subjects. The expression of IL-12B) were associated with the risk of developing colorectal cancer (CRC). Results:Compared with TTAGAG/TTAGAG genotype of rs17860508, the GC/GC and TTAGAG/GC genotypes may significantly increase the risk of CRC (OR?=?1.81, 95% CI?=?1.18-2.78; OR?=?1.46, 95% CI?=?1.01-2.12, respectively). Furthermore, the mRNA levels of IL-12B) were associated with the risk of developing colorectal cancer (CRC). P=0.009) and TTAGAG/TTAGAG (P=0.009) and TTAGAG/TTAGAG (. Conclusion:These data suggested that the rs17860508 GC/GC genotype might upregulate IL-12B expression at the transcriptional level and thus increase the risk of CRC.IL-12B) were associated with the risk of developing colorectal cancer (CRC).

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7054766 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature