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U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients.

ABSTRACT: Background. No study has examined the effect of low serum uric acid (SUA) concentrations on mortality in hypertrophic cardiomyopathy (HCM) patients. The aim of the present study was to assess the relations between both low and high SUA concentrations and the risk of mortality across the full range of SUA concentrations in a retrospective cohort of HCM patients.Methods. A total of 454 HCM patients were enrolled in the study, and SUA concentrations were measured at baseline. The primary and secondary endpoints were all-cause mortality and HCM-related mortality, respectively. The associations between SUA concentrations and endpoints were analysed.Results. During a median follow-up of 3.8?years, there were 80 (17.6%) all-cause mortality events, and 52 of them (11.5%) were ascribed to HCM-related mortality. Patients with SUA concentrations of 250-350?µmol/L had the lowest all-cause mortality rate (11.8%) and HCM-related mortality rate (5.0%). Both low and high SUA concentrations were associated with increased all-cause and HCM-related mortality. Adjusted HRs were 2.52 (95% CI 1.13-5.61, p?=?0.024) and 4.86 (95% CI 1.74-13.58, p?=?0.003) for all-cause mortality and HCM-related mortality in the lowest SUA group (<250?µmol/L) when compared with the reference group (250-350?µmol/L), respectively. The corresponding HRs in the highest SUA group (?450?µmol/L) were 2.73 (95% CI 1.42-5.23, p?=?0.003) and 4.14 (95% CI 1.70-10.13, p?=?0.002), respectively.Conclusions. Both low and high SUA concentrations were significantly associated with increased risk of all-cause mortality and HCM-related mortality, which supported a U-shaped association between SUA concentrations and mortality in HCM patients.

SUBMITTER: Wang Z

PROVIDER: S-EPMC7054957 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients.

Wang Ziqiong Z Xu Ying Y Liao Hang H Chen Xiaoping X He Sen S

Upsala journal of medical sciences 20200204 1

<b>Background</b>. No study has examined the effect of low serum uric acid (SUA) concentrations on mortality in hypertrophic cardiomyopathy (HCM) patients. The aim of the present study was to assess the relations between both low and high SUA concentrations and the risk of mortality across the full range of SUA concentrations in a retrospective cohort of HCM patients.<b>Methods.</b> A total of 454 HCM patients were enrolled in the study, and SUA concentrations were measured at baseline. The prim ...[more]

PMID: 32013714

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Project description:Objective:There is no consensus on the role of abnormal uric acid (UA) levels in the prognosis of patients undergoing hemodialysis. We therefore aimed to investigate the effects of changes in UA concentration on the risk of all-cause death and cardiac death in such patients. Method:In this retrospective cohort study, patients admitted to two hemodialysis centers performing maintenance hemodialysis (MHD) in Wuhan First Hospital and Fourth Hospital Hemodialysis Center from January 1, 2007, to October 31, 2017, were included. Results:In all, 325 patients undergoing MHD aged 59.7 ± 14.7 years, including 195 men (60%), were enrolled, with a median follow-up of 37 months. Serum UA (p < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (p < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (p < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (p < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (p < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (p < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (p < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (p < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (. Conclusion:Low UA levels were closely related to all-cause mortality in patients undergoing MHD. Although UA levels had no significant effect on cardiac death, they had a good predictive value for long-term prognosis in patients on MHD.

Dataset Information

U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients.

Publications

U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients.

Similar Datasets

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