Dataset Information

When it hurts even more: The neural dynamics of pain and interpersonal emotions.

ABSTRACT:

Objective

Chronic pain is highly prevalent among patients with mood, anxiety, personality, and somatic symptom disorders; and patients with chronic pain often suffer from persistent interpersonal distress. However, the neural mechanisms underlying this phenomenon and its possible role in the etiology of chronic pain are not yet understood. Based on our Developmental Theory of Centralized/Somatoform Pain, and prior research suggesting the existence of a shared neural system subserving interpersonal emotions and pain, we aimed to identify the neural basis for modulation of pain by feelings of interpersonal rejection and the role of the early interpersonal environment in development of this shared neural system.

Methods

During fMRI scanning, 22 healthy participants received moderately painful thermal stimuli in 3 interpersonal contexts: Acceptance, Rejection, and Reacceptance (modified Cyberball paradigm). Early interpersonal environment was assessed using the Parental Bonding Instrument.

Results

Interpersonal context modulated activity in pain neural systems during rejection and during accepting interactions with previously rejecting others. Moreover, the subjective perception of rejection, even when rejection was not occurring, correlated positively with reported pain severity and neural activity in the insula. The magnitude of neural modulation in pain circuits by feelings of rejection was associated with the quality of early interpersonal experience with caregivers.

Conclusions

Results suggest that interpersonal emotions play an important role in the development and functioning of the pain system, supporting our Developmental Theory of predisposition to chronic centralized pain. These findings have direct implications for clinical practice, including the importance of treating interpersonal distress to alleviate pain.

SUBMITTER: Landa A

PROVIDER: S-EPMC7055518 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

When it hurts even more: The neural dynamics of pain and interpersonal emotions.

Landa Alla A Fallon Brian A BA Wang Zhishun Z Duan Yunsuo Y Liu Feng F Wager Tor D TD Ochsner Kevin K Peterson Bradley S BS

Journal of psychosomatic research 20191126

<h4>Objective</h4>Chronic pain is highly prevalent among patients with mood, anxiety, personality, and somatic symptom disorders; and patients with chronic pain often suffer from persistent interpersonal distress. However, the neural mechanisms underlying this phenomenon and its possible role in the etiology of chronic pain are not yet understood. Based on our Developmental Theory of Centralized/Somatoform Pain, and prior research suggesting the existence of a shared neural system subserving int ...[more]

PMID: 31835079

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Project description:Numerical categories such as parity, i.e., being odd or even, have frequently been shown to influence how particular numbers are processed. Mathematically, number parity is defined categorically. So far, cognitive, and psychological accounts have followed the mathematical definition and defined parity as a categorical psychological representation as well. In this manuscript, we wish to test the alternative account that cognitively, parity is represented in a more gradual manner such that some numbers are represented as "more odd" or "more even" than other odd or even numbers, respectively. Specifically, parity processing might be influenced by more specific properties such as whether a number is a prime, a square number, a power of 2, part of a multiplication table, divisible by 4 or by 5, and many others. We suggest that these properties can influence the psychologically represented parity of a number, making it more or less prototypical for odd- or evenness. In the present study, we tested the influence of these numerical properties in a bimanual parity judgment task with auditorily presented two-digit numbers. Additionally, we further investigated the interaction of these numerical properties with linguistic factors in three language groups (English, German, and Polish). Results show significant effects on reaction times of the congruity of parity status between decade and unit digits, even if numerical magnitude and word frequency are controlled. We also observed other effects of the above specific numerical properties, such as multiplication attributes, which facilitated or interfered with the speed of parity judgment. Based on these effects of specific numerical properties we proposed and elaborated a parity continuum account. However, our cross-lingual study also suggests that parity representation and/or access seem to depend on the linguistic properties of the respective language or education and culture. Overall, the results suggest that the "perceived" parity is not the same as objective parity, and some numbers are more prototypical exemplars of their categories.

Dataset Information

When it hurts even more: The neural dynamics of pain and interpersonal emotions.

Objective

Methods

Results

Conclusions

Publications

When it hurts even more: The neural dynamics of pain and interpersonal emotions.

Similar Datasets

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