Synthetic ablations in the C. elegans nervous system.
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ABSTRACT:
SUBMITTER: Towlson EK
PROVIDER: S-EPMC7055645 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Synthetic ablations in the <i>C. elegans</i> nervous system.
Towlson Emma K EK Barabási Albert-László AL
Network neuroscience (Cambridge, Mass.) 20200301 1
Synthetic lethality, the finding that the simultaneous knockout of two or more individually nonessential genes leads to cell or organism death, has offered a systematic framework to explore cellular function, and also offered therapeutic applications. Yet the concept lacks its parallel in neuroscience-a systematic knowledge base on the role of double or higher order ablations in the functioning of a neural system. Here, we use the framework of network control to systematically predict the effect ...[more]
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