Non-Parametric Combined Reference Regions and Prediction of Clinical Risk.

ABSTRACT:

Background

Many clinical decisions depend on estimating patient risk of clinical outcomes by interpreting test results relative to reference intervals, but standard application of reference intervals suffers from two major limitations that reduce the accuracy of clinical decisions: (1) each test result is assessed separately relative to a univariate reference interval, ignoring the rich pathophysiologic information in multivariate relationships, and (2) reference intervals are intended to reflect a population's biological characteristics and are not calibrated for outcome prediction.

Methods

We developed a combined reference region (CRR), derived CRRs for some pairs of complete blood count (CBC) indices (RBC, MCH, RDW, WBC, PLT), and assessed whether the CRR could enhance th

SUBMITTER: Malka R 

PROVIDER: S-EPMC7055670 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature