Ontology highlight
ABSTRACT:
SUBMITTER: Tsukumo Y
PROVIDER: S-EPMC7055889 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Tsukumo Yoshinori Y Naito Mikihiko M Suzuki Takayoshi T
PloS one 20200304 3
In non-small cell lung cancer (NSCLC), oncogenic driver mutations including those in KRAS and EGFR are typically mutually exclusive. However, recent reports indicate that multiple driver mutations are found in a certain percentage of cancers, and that the therapeutic responses of such cases with co-mutations of driver genes are largely unclear. Here, using CRISPR-Cas9-mediated genome editing, we generated isogenic cell lines harboring one or two copies of an EGFR-activating mutation from the hum ...[more]