Ontology highlight
ABSTRACT:
SUBMITTER: Penn WD
PROVIDER: S-EPMC7056298 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Science advances 20200304 10
Membrane proteins must balance the sequence constraints associated with folding and function against the hydrophobicity required for solvation within the bilayer. We recently found the expression and maturation of rhodopsin are limited by the hydrophobicity of its seventh transmembrane domain (TM7), which contains polar residues that are essential for function. On the basis of these observations, we hypothesized that rhodopsin's expression should be less tolerant of mutations in TM7 relative to ...[more]