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The benefits of combining water and land-based therapy.

ABSTRACT: As the general population ages and lives longer with chronic disease and related disability, an increasing number of individuals may be pre-cluded from participating and excelling in traditional land-based therapy or exercise alone, despite its known benefits. This article discusses the benefits of water as an exercise and therapeutic medium, as well as the value of combining both water and land modalities, which enhance the benefits of exercise synergistically. This combined water and land approach has the potential to help clients achieve greater therapeutic benefits and clinical outcomes. As an example, described in this article are the rationale and basic framework for one treatment paradigm supported by research literature, the Burdenko Method, which has utilized combined exercise in water and on land for over four decades. These perspectives will hopefully foster increased understanding and application of exercise principles and programs outside of traditional land-based approaches.

SUBMITTER: Carayannopoulos AG

PROVIDER: S-EPMC7056478 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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The benefits of combining water and land-based therapy.

Carayannopoulos Alexios G AG Han Alex A Burdenko Igor N IN

Journal of exercise rehabilitation 20200226 1

As the general population ages and lives longer with chronic disease and related disability, an increasing number of individuals may be pre-cluded from participating and excelling in traditional land-based therapy or exercise alone, despite its known benefits. This article discusses the benefits of water as an exercise and therapeutic medium, as well as the value of combining both water and land modalities, which enhance the benefits of exercise synergistically. This combined water and land appr ...[more]

PMID: 32161731

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Project description:BackgroundYouth engagement refers to the collaboration between researchers and youth to produce research. Youth engagement in health research has been shown to inform effective interventions aimed at improving health outcomes. However, limited evidence has identified promising practices to meaningfully engage youth. This synthesis aims to describe youth engagement approaches, frameworks, and barriers, as well as provide both evidence-based and youth-generated recommendations for meaningful engagement.Main bodyThis review occurred in two stages: 1) a narrative review of existing literature on youth engagement and 2) a Youth Advisory Council (YAC) to review and supplement findings with their perspectives, experiences, and recommendations. The terms 'youth engagement' and 'health research' were searched in Google Scholar, PubMed, Web of Science, Scopus, and PsycINFO. Articles and non-peer reviewed research works related to youth engagement in health research were included, reviewed, and summarized. The YAC met with research team members and in separate youth-only forums to complement the narrative review with their perspectives. Types of youth engagement include participation as research participants, advisors, partners, and co-investigators. Barriers to youth engagement were organized into youth- (e.g., time commitments), researcher- (e.g., attitudes towards youth engagement), organizational- (e.g., inadequate infrastructure to support youth engagement), and system-level (e.g., systemic discrimination and exclusion from research). To enhance youth engagement, recommendations focus on preparing and supporting youth by offering flexible communication approaches, mentorship opportunities, diverse and inclusive recruitment, and ensuring youth understand the commitment and benefits involved.ConclusionsTo harness the potential of youth engagement, researchers need to establish an inclusive and enabling environment that fosters collaboration, trust, and valuable contributions from youth. Future research endeavors should prioritize investigating the dynamics of power-sharing between researchers and youth, assessing the impact of youth engagement on young participants, and youth-specific evaluation frameworks.

Project description:Breast cancer (BC) is the most prevalent cancer in women worldwide. A systematic approach to BC treatment, comprising adjuvant and neoadjuvant chemotherapy (NAC), as well as hormone therapy, forms the foundation of the disease’s therapeutic strategy. The extracellular matrix (ECM) is a dynamic network that exerts a robust biological effect on the tumor microenvironment (TME), and it is highly regulated by several immunological components, such as chemokines and cytokines. It has been established that the ECM promotes the development of an immunosuppressive TME. Therefore, while analyzing the ECM of BC, immune-related genes must be considered. In this study, we used bioinformatic approaches to identify the most valuable ECM-related immune genes. We used weighted gene co-expression network analysis to identify the immune-related genes that potentially regulate the ECM and then combined them with the original ECM-related gene set for further analysis. Least absolute shrinkage and selection operator (LASSO) regression and SurvivalRandomForest were used to narrow our ECM-related gene list and establish an ECM index (ECMI) to better delineate the ECM signature. We stratified BC patients into ECMI high and low groups and evaluated their clinical, biological, and genomic characteristics. We found that the ECMI is highly correlated with long-term BC survival. In terms of the biological process, this index is positively associated with the cell cycle, DNA damage repair, and homologous recombination but negatively with processes involved in angiogenesis and epithelial–mesenchymal transition. Furthermore, the tumor mutational burden, copy number variation, and DNA methylation levels were found to be related to the ECMI. In the Metabric cohort, we demonstrated that hormone therapy is more effective in patients with a low ECMI. Additionally, differentially expressed genes from the ECM-related gene list were extracted from patients with a pathologic complete response (pCR) to NAC and with residual disease (RD) to construct a neural network model for predicting the chance of achieving pCR individually. Finally, we performed qRT-PCR to validate our findings and demonstrate the important role of the gene OGN in predicting the pCR rate. In conclusion, delineation of the ECM signature with immune-related genes is anticipated to aid in the prediction of the prognosis of patients with BC and the benefits of hormone therapy and NAC in BC patients.

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The benefits of combining water and land-based therapy.

Publications

The benefits of combining water and land-based therapy.

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