Ontology highlight
ABSTRACT:
SUBMITTER: Niu Y
PROVIDER: S-EPMC7056556 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Niu Yanling Y Bao Lei L Chen Yan Y Wang Chenliang C Luo Maowu M Zhang Bo B Zhou Mi M Wang Jennifer E JE Fang Yisheng V YV Kumar Ashwani A Xing Chao C Wang Yingfei Y Luo Weibo W
Cancer research 20200103 5
Hypoxia induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but their biological functions remain largely unknown. Here, we identified a hitherto uncharacterized hypoxia-induced lncRNA RAB11B-AS1 in breast cancer cells. RAB11B-AS1 is a natural lncRNA upregulated in human breast cancer and its expression is induced by hypoxia-inducible factor 2 (HIF2), but not HIF1, in response to hypoxia. RAB11B-AS1 enhanced the expression of angiogenic factors including VEGFA and ANGPTL ...[more]