Ontology highlight
ABSTRACT:
SUBMITTER: Shimamoto S
PROVIDER: S-EPMC7056940 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Shimamoto So S Nishimura Yohei Y Nagamatsu Go G Hamada Norio N Kita Haruka H Hikabe Orie O Hamazaki Nobuhiko N Hayashi Katsuhiko K
Proceedings of the National Academy of Sciences of the United States of America 20190530 25
In mammals, most immature oocytes remain dormant in the primordial follicles to ensure the longevity of female reproductive life. A precise understanding of mechanisms underlying the dormancy is important for reproductive biology and medicine. In this study, by comparing mouse oogenesis in vivo and in vitro, the latter of which bypasses the primordial follicle stage, we defined the gene-expression profile representing the dormant state of oocytes. Overexpression of constitutively active FOXO3 pa ...[more]