Ontology highlight
ABSTRACT:
SUBMITTER: Ungaro RC
PROVIDER: S-EPMC7057119 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ungaro Ryan C RC Limketkai Berkeley N BN Jensen Camilla Bjørn CB Allin Kristine Højgaard KH Agrawal Manasi M Ullman Thomas T Colombel Jean-Frederic JF Jess Tine T
Gut 20181112 6
<h4>Objective</h4>The benefit of continuing 5-aminosalicylate (5-ASA) in patients with ulcerative colitis (UC) who initiate anti-tumour necrosis factor-alpha (anti-TNF) biologics is unknown. We aimed to compare clinical outcomes in patients with UC already on 5-ASA who started anti-TNF and then either stopped or continued 5-ASA.<h4>Design</h4>Our primary outcome was any adverse clinical event defined as a composite of new corticosteroid use, UC-related hospitalisation or surgery. We used two nat ...[more]