Dataset Information

Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging.

ABSTRACT:

Purpose

To describe the migration of an outer retinal element using longitudinal multimodal imaging.

Observations

In the retina of a healthy 7-year-old girl, movement of a hyperreflective element of 15 μm extent was seen using optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (cSLO), and adaptive optics fundus photography (AO). On the OCT B-scan, the element initially appeared at the level of the outer limiting membrane with an umbra reaching the retinal pigment epithelium from where it gradually diminished and disappeared over 33 days. A corresponding disruption of the photoreceptor pattern on AO diminished over 52 days.

Conclusions and importance

This non-invasive observation of an isolated, cell-sized, migrating element in the human retina was made in vivo in the absence of confounding retinal disease or similar nearby elements. Based on prior preclinical observations we hypothesize that such a migrating element could be a macrophage. The case provides information about the time-scale and resolution needed for the monitoring of infiltrative processes in the retina.

SUBMITTER: Torm MEW

PROVIDER: S-EPMC7057146 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Publications

Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging.

Torm Marie Elise Wistrup MEW Belmouhand Mohamed M Munch Inger Christine IC Larsen Michael M Rothenbuehler Simon Paul SP

American journal of ophthalmology case reports 20200226

<h4>Purpose</h4>To describe the migration of an outer retinal element using longitudinal multimodal imaging.<h4>Observations</h4>In the retina of a healthy 7-year-old girl, movement of a hyperreflective element of 15 μm extent was seen using optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (cSLO), and adaptive optics fundus photography (AO). On the OCT B-scan, the element initially appeared at the level of the outer limiting membrane with an umbra reaching the retinal p ...[more]

PMID: 32154438

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Dataset Information

Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging.

Purpose

Observations

Conclusions and importance

Publications

Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging.

Similar Datasets

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