Ontology highlight
ABSTRACT:
SUBMITTER: Zhao W
PROVIDER: S-EPMC7057159 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhao Wei W Cui Yameng Y Liu Lina L Ma Xiaozhou X Qi Xiaoqian X Wang Yue Y Liu Zihao Z Ma Shiqing S Liu Jingwen J Wu Jie J
Molecular therapy. Nucleic acids 20200204
N<sup>6</sup>-Methyladenosine (m<sup>6</sup>A) is the most common internal modification of eukaryotic messenger RNA (mRNA) that occurred on the N<sup>6</sup> nitrogen of adenosine. However, the roles of m<sup>6</sup>A in oral squamous cell carcinoma (OSCC) are still elusive. Here, we investigate the function and mechanism of methyltransferase-like 3 (METTL3) in OSCC tumorigenesis. Clinically, METTL3 was significantly upregulated in tissue samples and correlated with the poor prognosis of OSCC pa ...[more]