Ontology highlight
ABSTRACT:
SUBMITTER: Choueiri TK
PROVIDER: S-EPMC7057274 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Choueiri Toni K TK Jacobus Susanna S Bellmunt Joaquim J Qu Angela A Appleman Leonard J LJ Tretter Christopher C Bubley Glenn J GJ Stack Edward C EC Signoretti Sabina S Walsh Meghara M Steele Graeme G Hirsch Michelle M Sweeney Christopher J CJ Taplin Mary-Ellen ME Kibel Adam S AS Krajewski Katherine M KM Kantoff Philip W PW Ross Robert W RW Rosenberg Jonathan E JE
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20140512 18
<h4>Purpose</h4>In advanced urothelial cancer, treatment with dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC) results in a high response rate, less toxicity, and few dosing delays. We explored the efficacy and safety of neoadjuvant ddMVAC with pegfilgrastim support in muscle-invasive urothelial cancer (MIUC).<h4>Patients and methods</h4>Patients with cT2-cT4, N0-1, M0 MIUC were enrolled. Four cycles of ddMVAC were administered, followed by radical cystectomy. The primar ...[more]