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ABSTRACT:
SUBMITTER: Deshmukh A
PROVIDER: S-EPMC7057346 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Deshmukh Ashish A Gopal Balasubramanian B
Acta crystallographica. Section F, Structural biology communications 20200303 Pt 3
The nonribosomal biosynthesis of the dipeptide antibiotic bacilysin is achieved by the concerted action of multiple enzymes in the Bacillus subtilis bac operon. BacF (YwfG), encoded by the bacF gene, is a fold type I pyridoxal 5-phosphate (PLP)-dependent stereospecific transaminase. Activity assays with L-phenylalanine and 4-hydroxyphenylpyruvic acid (4HPP), a chemical analogue of tetrahydrohydroxyphenylpyruvic acid (H<sub>4</sub>HPP), revealed stereospecific substrate preferences, a finding tha ...[more]