Brain BOLD MRI O₂ and CO₂ stress testing: implications for perioperative neurocognitive disorder following surgery.

ABSTRACT:

Background

Mechanical ventilation to alter and improve respiratory gases is a fundamental feature of critical care and intraoperative anesthesia management. The range of inspired O₂ and expired CO₂ during patient management can significantly deviate from values in the healthy awake state. It has long been appreciated that hyperoxia can have deleterious effects on organs, especially the lung and retina. Recent work shows intraoperative end-tidal (ET) CO₂ management influences the incidence of perioperative neurocognitive disorder (POND). The interaction of O₂ and CO₂ on cerebral blood flow (CBF) and oxygenation with alterations common in the critical care and operating room environments has not been well studied.

Methods

SUBMITTER: Mutch WAC 

PROVIDER: S-EPMC7057494 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature