Dataset Information

Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer's disease.

ABSTRACT:

Background

The Centiloid scale was developed to standardise the results of beta-amyloid (A?) PET. We aimed to determine the Centiloid unit (CL) thresholds for CERAD sparse and moderate-density neuritic plaques, Alzheimer's disease neuropathologic change (ADNC) score of intermediate or high probability of Alzheimer's Disease (AD), final clinicopathological diagnosis of AD, and expert visual read of a positive A? PET scan.

Methods

A? PET results in CL for 49 subjects were compared with post-mortem findings, visual read, and final clinicopathological diagnosis. The Youden Index was used to determine the optimal CL thresholds from receiver operator characteristic (ROC) curves.

Results

A threshold of 20.1 CL (21.3 CL when corrected for time to death, AUC 0.97) yielded highest accuracy in detecting moderate or frequent plaque density while ?45 CL. Positive visual read agreed highly with results >?26 CL.

Conclusions

Centiloid values ?20 CL indicated the presence of at least moderate plaque density, but approximately 50 CL or more best confirmed both neuropathological and clinicopathological diagnosis of Alzheimer's disease.

SUBMITTER: Amadoru S

PROVIDER: S-EPMC7057642 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Publications

Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer's disease.

Amadoru Sanka S Doré Vincent V McLean Catriona A CA Hinton Fairlie F Shepherd Claire E CE Halliday Glenda M GM Leyton Cristian E CE Yates Paul A PA Hodges John R JR Masters Colin L CL Villemagne Victor L VL Rowe Christopher C CC

Alzheimer's research & therapy 20200304 1

<h4>Background</h4>The Centiloid scale was developed to standardise the results of beta-amyloid (Aβ) PET. We aimed to determine the Centiloid unit (CL) thresholds for CERAD sparse and moderate-density neuritic plaques, Alzheimer's disease neuropathologic change (ADNC) score of intermediate or high probability of Alzheimer's Disease (AD), final clinicopathological diagnosis of AD, and expert visual read of a positive Aβ PET scan.<h4>Methods</h4>Aβ PET results in CL for 49 subjects were compared w ...[more]

PMID: 32131891

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Project description:BackgroundThe standard Centiloid (CL) method was proposed to harmonize and quantify global 18F-labeled amyloid beta (Aβ) PET ligands using MRI as an anatomical reference. However, there is need for harmonizing and quantifying regional Aβ uptakes between ligands using CT as an anatomical reference. In the present study, we developed and validated a CT-based regional direct comparison of 18F-florbetaben (FBB) and 18F-flutemetamol (FMM) Centiloid (rdcCL).MethodsFor development of MRI-based or CT-based rdcCLs, the cohort consisted of 63 subjects (20 young controls (YC) and 18 old controls (OC), and 25 participants with Alzheimer's disease dementia (ADD)). We performed a direct comparison of the FMM-FBB rdcCL method using MRI and CT images to define a common target region and the six regional VOIs of frontal, temporal, parietal, posterior cingulate, occipital, and striatal regions. Global and regional rdcCL scales were compared between MRI-based and CT-based methods. For clinical validation, the cohort consisted of 2245 subjects (627 CN, 933 MCI, and 685 ADD).ResultsBoth MRI-based and CT-based rdcCL scales showed that FMM and FBB were highly correlated with each other, globally and regionally (R2 = 0.96~0.99). Both FMM and FBB showed that CT-based rdcCL scales were highly correlated with MRI-based rdcCL scales (R2 = 0.97~0.99). Regarding the absolute difference of rdcCLs between FMM and FBB, the CT-based method was not different from the MRI-based method, globally or regionally (p value = 0.07~0.95). In our clinical validation study, the global negative group showed that the regional positive subgroup had worse neuropsychological performance than the regional negative subgroup (p < 0.05). The global positive group also showed that the striatal positive subgroup had worse neuropsychological performance than the striatal negative subgroup (p < 0.05).ConclusionsOur findings suggest that it is feasible to convert regional FMM or FBB rdcSUVR values into rdcCL scales without additional MRI scans. This allows a more easily accessible method for researchers that can be applicable to a variety of different conditions.

Dataset Information

Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer's disease.

Background

Methods

Results

Conclusions

Publications

Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer's disease.

Similar Datasets

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